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P P en yroyal Summary and Pharmaceutical Comment Dosage Interest in pennyroyal has focused on the toxicity associated Dosages for oral administration (adults) for traditional uses with the volatile oil. No documented reports of the recommended in standard herbal reference texts are given below. Part(s) Used Sideeffects, Toxicity Herb Clinical data the toxicity of pennyroyal oil is well recognised and human Pharmacopoeial and Other Monographs fatalities following its ingestion as an abortifacient have been (G7) reported. Generally, doses required for an Legal Category (Licensed Products) abortifacient effect are also toxic and fatalities have involved (G37) both nephrotoxicity and hepatotoxicity. Steroid (pregneno information available for an adequate assessment of toxicity lone16acarbonitrile) treatment has reduced hepatotoxicity (but see Sideeffects, Toxicity). Traditionally, it has been used for flatulent dyspepsia, intestinal colic, common cold, delayed menstruation, and topically for cutaneous eruptions, formication and gout. P P ilew ort Summary and Pharmaceutical Comment Constituents Limited information is available on the chemistry of pilewort. The following is compiled from several sources, including General Little scientific information was located to justify the herbal References G40 and G42. There is a lack of clinical research assessing the efficacy and safety of pilewort. In view of the toxic and irritant Triterpenoids Glycosides based on the sapogenins hederagenin properties stated for protoanemonin, the excessive use of and oleanolic acid, with arabinose, glucose and rhamnose, as (1) pilewort and use during pregnancy and lactation should be sugar moieties. Clinical studies There is a lack of clinical research assessing the effects of pilewort and rigorous randomised clinical trials are required. Sideeffects, Toxicity There is a lack of clinical safety and toxicity data for pilewort and protoanemonin may depend on the inactivation of enzymes further investigation of these aspects is required. In view of this, the use of pilewort during pregnancy and lactation should be avoided. A triterpenoid saponin from Ficaria ranunculoides ure 2 Pilewort (Ranunculus ficaria). P lan tain acid, ursolic acid, vanillic acid;(1, 2) oleanolic acid and ascorbic Summary and Pharmaceutical Comment acid. The constituents of plantain are welldocumented and the Alkaloids Trace (unspecified), (3, 4) boschniakine and the methyl reputed antihaemorrhagic properties may be attributable to ester of boschniakinic acid(5) the tannin constituents. The toxicity of plantain is reported to be low, but (6) leucine, serine and tryptophan. Carbohydrates LFructose, Dglucose, planteose, saccharose, stachyose, dxylose, sorbitol, tyrosol, mucilage and gum. Synonym(s) Iridoids Aucubin, aucubin derivatives, plantarenaloside, aucubo side and melitoside.

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Gabapentin for relief of neuropathic pain related to anticancer treatment: a preliminary study. Peripheral neuropathy due to therapy with paclitaxel, gemcitabine, and cisplatin in patients with advanced ovarian cancer. Nephrology consultation for patients with hypertension, Medical Conditions Urinalysis proteinuria, or progressive renal insuffciency. Neurocognitive functioning in adult survivors of childhood noncentral nervous system cancers. Treatment Factors Seizures Neurology consultation and followup as clinically indicated. Longterm followup of children with 6thioguaninerelated chronic hepatoxicity following treatment for acute lymphoblastic leukaemia. Prevention of rickets and vitamin D defciency in infants, children, and adolescents. Effect of hydration on methotrexate plasma concentrations in children with acute lymphocytic leukemia. Highdose methotrexate administration and acute liver damage in children treated for acute lymphoblastic leukemia. Transient acute hepatotoxicity of highdose methotrexate therapy during childhood. Effects of chemotherapy on neurocognitive function in children with acute lymphoblastic leukemia: a critical review of the literature. A comparison of neurocognitive functioning in children previously randomized to dexamethasone or prednisone in the treatment of childhood acute lymphoblastic leukemia. Increased P2 sound on screening evaluations, left ventricular dysfunction, doses of doxorubicin. Baseline at entry into longterm follow Doxorubicin: Multiply total up, then periodically based on age at dose x 1 treatment, radiation dose, and cumulative Daunorubicin: Multiply total anthracycline dose. Chronic progressive cardiac dysfunction years after doxorubicin therapy for childhood acute lymphoblastic leukemia. Cardiac outcomes in a cohort of adult survivors of childhood and adolescent cancer: retrospective analysis of the Childhood Cancer Survivor Study cohort. Obesity 18 years or older at time of weight, blood pressure and hearthealthy diet. Counsel regarding Info Link (Mitoxantrone): Childhood cancer patients Congenital heart disease treatment appropriate exercise.

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The propensity score matched cox regression analysis did not show a difference in 5year survival between patients who filed for bankruptcy and their counterparts who did not file for bankruptcy (p=0. Conclusions: Among Indiana breast cancer patients, younger age, residency in a high poverty area, no insurance at diagnosis, and regional disease at diagnosis increased the probability of filing for bankruptcy after a diagnosis of breast cancer. Contrary to other published studies, filing for bankruptcy did not 220 increase allcause mortality in this cohort. Since government insurance at diagnosis was protective against filing for bankruptcy, future studies should focus on how state expansion of Medicaid can be leveraged to reduce health care costbased bankruptcies in the state. In addition, programs should be developed to help treating providers identify atrisk patients and refer them to appropriate financial services. Explanations for this disparity may include socioeconomic factors, late cancer detection, and tumor biology. The objective of this study is to determine if there are differences in presentation, treatment, and 5year allcause mortality between insured black and white women undergoing treatment for breast cancer in Indiana. Bivariate analysis using logrank tests and Kaplan Meier curves compared the groups. A multivariable cox proportional hazard model was used to evaluate the relationship between race and allcause mortality after controlling for sociodemographic, comorbidities, stage and tumor characteristics, and treatment variables. Results: A total of 7062 insured breast cancer patients were identified from 20082014. There was no difference between the groups on the receipt of radiation therapy (p=0. Furthermore, there was no difference in 5year, allcause mortality between the racial groups on unadjusted Kaplan Meier analysis (p=0. Conclusions: Despite lower socioeconomic status and worse diseaserelated prognostic factors, black women in this study experienced similar treatment modalities, did not experience treatment delays, and had equivalent allcause mortality to white women. These results indicate equivalent access to care and subsequent treatment may diminish disparities in mortality among black Indiana breast cancer patients. Furthermore, a small pilot study completed at our institution demonstrated that Hispanic women were diagnosed with breast cancer at significantly younger ages than Caucasian women. Given these observations, we sought to evaluate differences in the distribution of age and stage of breast cancer at the time of diagnosis between racial groups within a safety net hospital in a larger cohort in order to explore the greater question of whether underserved, racially diverse populations are underscreened. Methods: All female patients with breast cancer diagnosed between 19962016 at our institution were included. Diagnoses determined to represent a breast cancer recurrence were excluded from this analysis. Patient demographics (age at diagnosis and ethnicity) as well as cancer characteristics (clinical stage at diagnosis and receptor status) were collected. Median age, clinical stage, and proportions of patients diagnosed younger than age 40 and diagnosed at Stage 0 or 1 were compared among racial groups. Hispanic women were diagnosed at a median age of 51 years (range 20110), significantly younger than other race groups (p<0.

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Tularemia epidemic in Northwestern Spain: Clinical description and therapeutic response. Laboratory analysis of tularemia in wild trapped, commercially distributed prairie dogs, Texas; 2002. Comparison of enzymelinked immunosorbent assay, Western blotting, microagglutination, indirect immunofuorescence assay, and fow cytometry for serological diagnosis of tularemia. Risk of occupationally acquired illness from biological threat agents in unvaccinated laboratory workers. Characterization and classifcation of strains of Francisella tularensis isolated in the central Asian focus of the Soviet Union and in Japan. Fatal infection caused by Francisella tularensis in a neutropenic bone marrow transplant recipient. Pathogenesis of tularemia in monkeys aerogenically exposed to Francisella tularensis 425. Exposure of laboratory workers to Francisella tularensis despite a bioterrorism procedure. Susceptibility of various mouse strains to aerosol initiated tularemia by virulent type A Francisella tularensis before and after immunization with the attenuated live vaccine strain of the pathogen. Epidemiologic and molecular analysis of human tularemia in the United States, 19642004. Peripheral blood leukocyte counts, erythrocyte sedimentation rate and C reactive protein in tularemia caused by the type B strain of Francisella tularensis. In vitro susceptibility of Francisella tularensis to fuoroquinolones and treatment of tularemia with norfoxacin and ciprofoxacin. Cellmediated and humoral immune responses induced by scarifcation vaccination of human volunteers with a new lot of the live vaccine strain of Francisella tularensis. Cellmediated and humoral immune responses after vaccination of human volunteers with the live vaccine strain of Francisella tularensis. Immunogenicity of a new lot of Francisella tularensis live vaccine strain in human volunteers. Bioavailability of tetracycline and doxycycline in fasted and non fasted subjects. Characterization of a novicidalike subspecies of Francisella tularensis isolated in Australia.

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