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Sympathotonic orthostatic intolerance Inability to tolerate standing up that is associated with excessive activity of the sympathetic nervous system. Symptom A complaint about something abnormal a person notices that provides subjective evidence of a disease. In syncope the sudden loss of consciousness is associated with loss of muscle tone and the regaining of consciousness within seconds to minutes. Synucleinopathies A family of diseases characterized by deposition of the protein, alpha-synuclein, in the cytoplasm of affected cells. Takotsubo cardiopathy A form of stress-related acute heart failure that is most common in post-menopausal women and probably due to high catecholamine levels. Tardive dyskinesia A complication of dopamine receptor antagonists that involves involuntary movements of the jaw or tongue. Teleology is a reason or explanation for something in terms of its purpose or goal. Thoracolumbar spinal cord the mid-portion of the spinal cord from which sympathetic nerves emerge. Tilt table testing A test where the patient is tilted on a platform, to assess the ability of the patient to tolerate and respond appropriately to standing up. Tomography (or tomographic scan) A type of scan where a part of the body is visualized in slices. Total peripheral vascular resistance Synonymous with total peripheral resistance, the total amount of resistance to blood flow in the body. Trimethaphan infusion test A test where trimethaphan is given by vein, to assess the effects on blood pressure. Tryptase An enzyme found in granules of mast cells that has been used as a marker for mast cell activation. Uptake-2 Uptake of norepinephrine and related chemicals by way of a transporter on non-neuronal cells such as myocardial cells. Vagal parasympathetic outflow Traffic in the vagus nerve, a main nerve of the parasympathetic nervous system. Vagusstoff A term used by Otto Loewi referring to the chemical messenger released from the stimulated vagus nerve. Loewi identified the Vagusstoff as acetylcholine, and for this discovery he received a Nobel Prize. Valsalva maneuver A maneuver where a person blows againsta resistance or strains against a clossed glottis, resulting in an increase in pressure in the chest and a decrease in the 741 Principles of Autonomic Medicine v. Vasodepressor syncope Same as Autonomically Mediated Syncope, Reflex Syncope, Neurocardiogenic syncope, and Neurally Mediated Syncope.

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Combination treatment with an alpha-blocker plus an anticholinergic for bladder outlet obstruction: a prospective, randomized, controlled study. Fistulas of the lower urinary tract: percutaneous approaches for the management of a difficult clinical entity. Gamma-aminobutyric acid as a promoting factor of cancer metastasis; induction of matrix metalloproteinase production is potentially its underlying mechanism. Photoselective vaporization of the prostate: the basel experience after 108 procedures. Development of a multiregional United States Spanish version of the international prostate symptom score and the benign prostatic hyperplasia impact index. Coping with bladder exstrophy: diverse results from early attempts at functional urinary tract surgery. Results of a questionnaire evaluating the effects of different methods of toilet training on achieving bladder control. Discontinuation of alpha-blockade after initial treatment with finasteride and doxazosin for bladder outlet obstruction. Discontinuation of alpha-blockade after initial treatment with finasteride and doxazosin in men with lower urinary tract symptoms and clinical evidence of benign prostatic hyperplasia. Determination of transition zone volume by transrectal ultrasound in patients with clinically benign prostatic hyperplasia: agreement with enucleated prostate adenoma weight. Heritability of prostate-specific antigen and relationship with zonal prostate volumes in aging twins. Incidence of hypertension in individuals with different blood pressure salt-sensitivity: results of a 15-year follow-up study. A system for studying epithelial-stromal interactions reveals distinct inductive abilities of stromal cells from benign prostatic hyperplasia and prostate cancer. Treatment of lower urinary tract symptoms suggestive of benign prostatic hyperplasia: the cardiovascular system. Binding of mepartricin to sex hormones, a key factor of its activity on benign prostatic hyperplasia. Urinary retention after bilateral extravesical ureteral reimplantation: does dissection distal to the ureteral orifice have a role. Comparative analysis of the frequency of lower urinary tract dysfunction among institutionalised and non institutionalised children. Filling and voiding symptoms in the American Urological Association symptom index: the value of their distinction in a Veterans Affairs randomized trial of medical therapy in men with a clinical diagnosis of benign prostatic hyperplasia.

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Of the remaining six, two Class 2 5,6 7,8,16,17 studies and four Class 3 studies were included as evidence for this topic. Seven Class 3 9-15 studies from the 3rd Edition were also included for this topic. Class 2 Studies the evidence from the Class 2 studies of advanced cerebral monitoring thresholds is summarized in Table 18-2. Summary of Evidence: Class 2 Studies (Advanced Cerebral Monitoring Thresholds) Reference, Results Study Topic Study Design, N, and Outcomes Data Class Conclusion Brain Tissue Oxygen Monitoring 5 Eriksson, 2012* Retrospective Cohort Class 2 Mortality is higher when PbrO2 N=32 remains below 29 mm Hg in the 1st To determine the Survived=22 72 hours. Note: Different abbreviations such as pBtO2/PbtO2 and PtiO2 are used to mean brain tissue oxygen monitoring and brain tissue oxygen tension; we use PbrO2 for consistency, which may differ from what the study authors used. The PbrO2 values were significantly higher in survivors at 8, 12, 20-44, 52-60, and 72 hours (p<0. The threshold most predictive of mortality was 29 mm Hg, with survivors having a longer period of time with PbrO2 29 during the first 72 hours of monitoring (hours, 52. Class 3 Studies the evidence from the Class 3 studies of advanced cerebral monitoring thresholds is summarized in Table 18-3. When the brain United States tissue O2 level was less than 20 mm Hg and did not improve during Mortality resuscitation, the mortality rate was 60%. Favorable outcome: 73% Unfavorable outcome: 18% Death: 9% Patients (n=23) with PbrO2 <10 mm Hg for >30 minutes had rates of: Favorable outcome: 22% Unfavorable outcome: 22% Death: 56%. Low PbrO2 values and the duration of time spent with low PbrO2 are associated with mortality. Time spent with a low PbrO2 was related to outcome as follows: PbrO2 <5 mm Hg of 30 minutes duration was associated with a 50% risk of death. PbrO2 <10 mm Hg of 1 hour 45 minutes duration was associated with a 50% risk of death. A 50% risk of death was associated with a PbrO2 less than 15 mm Hg lasting longer than 4 hours. The number of desaturation episodes were related to outcome as follows: Good recovery/moderate disability No episodes: 44% One episode: 30% Multiple episodes. Different abbreviations such as pBtO2/PbtO2 and PtiO2 are used to mean brain tissue oxygen monitoring and brain tissue oxygen tension; we use PbrO2 for consistency, which may differ from what the study authors used. A total of 222 patients were observed across studies, with sample sizes ranging 7 8 from 25 to 101. One showed increasingly poor outcomes as thresholds moved from <25 to <20 and <15 mm Hg. Three were conducted in single centers, while 15 one collected data in two hospitals. The two Robertson studies suggest that a SjO2 value of 50% is a critical threshold to avoid.

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Analysis of the inflammatory network in benign prostate hyperplasia and prostate cancer. Expression of protein kinase C isoenzymes in benign hyperplasia and carcinoma of prostate. Intra and inter-investigator variation in the analysis of pressure-flow studies in men with lower urinary tract symptoms. Nocturnal polyuria in patients with lower urinary tract symptoms and response to alpha-blocker therapy. Is reduced quality of life in men with lower urinary tract symptoms due to concomitant diseases. Hirudin as anticoagulant for cardiopulmonary bypass: importance of preoperative renal function. Response to sublethal heat treatment of prostatic tumor cells and of prostatic tumor infiltrating T-cells. Interstitial laser coagulation in benign prostatic hyperplasia: A critical evaluation after 2 years of follow-Up. Classification, epidemiology and implications of chronic prostatitis in North America, Europe and Asia. Inconsistent localization of gram-positive bacteria to prostate-specific specimens from patients with chronic prostatitis. Redo ureteroneocystostomy using an extravesical approach in pediatric renal transplant patients with reflux: a retrospective analysis and description of technique. Race/ethnicity, obesity, health related behaviors and the risk of symptomatic benign prostatic hyperplasia: results from the prostate cancer prevention trial. Soft-copy versus hard-copy interpretation of voiding cystourethrography in neonates, infants, and children. Nocturia in patients with lower urinary tract symptoms: association with diurnal voiding patterns. Assessment of a fragment of e-cadherin as a serum biomarker with predictive value for prostate cancer. Re: histological changes of minimally invasive procedures for the treatment of benign prostatic hyperplasia and prostate cancer: clinical implications. Photoselective vaporization of the prostate: a volume reduction analysis in patients with lower urinary tract symptoms secondary to benign prostatic hyperplasia and carcinoma of the prostate. The benefits of radical prostatectomy beyond cancer control in symptomatic men with prostate cancer. Does perioperative outcome of transurethral holmium laser enucleation of the prostate depend on prostate size. The relationships of urethral and pelvic floor muscles and the urethral pressure measurements in women with stress urinary incontinence. Analysis of the pathophysiology of lower urinary tract symptoms in patients after prostatectomy.