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The promotion of hair growth and prevention of hair loss by ginseng and its metabolites are associated with the induction of anagen and delaying of catagen phases. Although the underlying mechanisms by which ginseng and its metabolites regulate hair cycling have been explored to a limited extent, further studies, especially focusing on extended human trials, are required to establish this natural remedy for hair loss. Alopecia, originating from a variety of causes, including hyperactivation of androgenic signals, exposure to chemotherapeutics, aging, or skin photodamage, is considered as a skin pathology and has great psychosocial impact. Molecular mechanisms underlying hair-proliferative and antiapoptosis-inducing activity of ginseng. Type Study Model Dosage Action Mechanism Target Reference Fructus panax Human hair dermal papilla cells 0. Acknowledgments: I wish to thank Joydeb Kumar Kundu for his helpful comments on the manuscript. Stereoselective suppressive effects of protopanaxadiol epimers on uv-b-induced reactive oxygen species and matrix metalloproteinase-2 in human dermal keratinocytes. Phytochemical investigation and hair growth studies on the rhizomes of nardostachys jatamansi dc. Bioassay of crude drugs for hair growth promoting activity in mice by a new simple method. Protective effect of korean red ginseng against chemotherapeutic drug-induced premature catagen development assessed with human hair follicle organ culture model. Effects of ginseng saponins isolated from red ginseng on ultraviolet B-induced skin aging in hairless mice. Ginsenoside F1 protects human hacat keratinocytes from ultraviolet-B-induced apoptosis by maintaining constant levels of Bcl-2. Panax ginseng induces human Type I collagen synthesis through activation of smad signaling. Protopanaxatirol type ginsenoside re promotes cyclic growth of hair follicles via inhibiting transforming growth factor? Control of human hair growth by neurotrophins: Brain-derived neurotrophic factor inhibits hair shaft elongation, induces catagen, and stimulates follicular transforming growth factor? Protective effects of korean red ginseng against radiation-induced apoptosis in human hacat keratinocytes. A role for p75 neurotrophin receptor in the control of apoptosis-driven hair follicle regression. Inhibitory effects of polyacetylene compounds from panax ginseng on neurotrophin receptor-mediated hair growth. Ginsenoside rg3 up-regulates the expression of vascular endothelial growth factor in human dermal papilla cells and mouse hair follicles.
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Su1190: Development of a score for differential diagnosis between intestinal tuberculosis and Crohn?s disease: a prospective study [abstract]. Ultrasound as a diagnostic tool in detecting active Crohn?s disease: a meta-analysis of prospective studies. Is magnetic resonance imaging a reliable diagnostic tool in the evaluation of active Crohn?s disease in the small bowel? A systematic review of the measurement of endoscopic healing in ulcerative colitis clinical trials: recommendations and implications for future research. Fiber in the treatment and maintenance of inflammatory bowel disease: a systematic review of randomized controlled trials. Thiopurine dose in intermediate and normal metabolizers of thiopurine methyltransferase may differ three-fold. Methotrexate in combination with infliximab is no more effective than infliximab alone in patients with Crohn?s disease. Hepatotoxicity caused by methotrexate therapy in children with inflammatory bowel disease: a systematic review and meta-analysis. Biological agents for moderately to severely active ulcerative colitis: a systematic review and network metaanalysis. Antibodies to infliximab and risk of infusion reactions in patients with inflammatory bowel disease: a systematic review and meta-analysis. Infliximab reduces hospitalizations and surgery interventions in patients with inflammatory bowel disease: a systematic review and meta-analysis. Adalimumab for Crohn?s disease after infliximab treatment failure: a systematic review. Systematic review with network meta-analysis: the efficacy of anti-tumour necrosis factor-alpha agents for the treatment of ulcerative colitis. Effect of probiotics on inducing remission and maintaining therapy in ulcerative colitis, Crohn?s disease, and pouchitis: meta-analysis of randomized controlled trials. Stapled side-to-side anastomosis might be better than handsewn end-to-end anastomosis in ileocolic resection for Crohn?s disease: a meta-analysis. The role of thiopurines in reducing the need for surgical resection in Crohn?s disease: a systematic review and meta-analysis. Preoperative infliximab use and postoperative complications in Crohn?s disease: a systematic review and meta-analysis. Efficacy and safety of granulocyte and monocyte adsorption apheresis for ulcerative colitis: a meta-analysis. General Warfarin sodium is an orally administered anticoagulant drug that is marketed most commonly as Coumadin?. Pharmacogenomics as a science examines associations among variations in genes with individual responses to a drug or medication. This would be an once-in-a-lifetime test, absent any reason to believe that the patient?s personal genetic characteristics would change over time.
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Published studies of percutaneous heart valves (Questions 3-4) (continued) Study Study Patients Intervention Outcomes Adverse events Comments characteristics Bleiziffer, Country/countries: No. Published studies of percutaneous heart valves (Questions 3-4) (continued) Study Study Patients Intervention Outcomes Adverse events Comments characteristics Bojara, Country/countries: No. Published studies of percutaneous heart valves (Questions 3-4) (continued) Study Study Patients Intervention Outcomes Adverse events Comments characteristics Study objective(s): cardiovascular/? We report a Surgical Implantation approach: 2) Change in valve area: cerebrovascular 2 transcatheter mitral indication(s): Transapical 0. Published studies of percutaneous heart valves (Questions 3-4) (continued) Study Study Patients Intervention Outcomes Adverse events Comments characteristics Clavel, Country/countries: No. Published studies of percutaneous heart valves (Questions 3-4) (continued) Study Study Patients Intervention Outcomes Adverse events Comments characteristics 25 Basic design: Case 91) mm 1) Change in valve area: Leak: Tron, et al. Published studies of percutaneous heart valves (Questions 3-4) (continued) Study Study Patients Intervention Outcomes Adverse events Comments characteristics Primary: Study the expanding? Published studies of percutaneous heart valves (Questions 3-4) (continued) Study Study Patients Intervention Outcomes Adverse events Comments characteristics menthal, Age: 85 Major Kempfert, Setting: Surgical Size of catheter: 27 Fr Hemodynamic cardiovascular/ et al. Published studies of percutaneous heart valves (Questions 3-4) (continued) Study Study Patients Intervention Outcomes Adverse events Comments characteristics endocarditis Excessive femoral, iliac or aortic atherosclerosis Grube, Country/countries: No. Published studies of percutaneous heart valves (Questions 3-4) (continued) Study Study Patients Intervention Outcomes Adverse events Comments characteristics Grube, Country/countries: No. Published studies of percutaneous heart valves (Questions 3-4) (continued) Study Study Patients Intervention Outcomes Adverse events Comments characteristics Hanzel, Country/countries: No. Published studies of percutaneous heart valves (Questions 3-4) (continued) Study Study Patients Intervention Outcomes Adverse events Comments characteristics Himbert, Country/countries: No. Published studies of percutaneous heart valves (Questions 3-4) (continued) Study Study Patients Intervention Outcomes Adverse events Comments characteristics Kapadia, Country/countries: No. Published studies of percutaneous heart valves (Questions 3-4) (continued) Study Study Patients Intervention Outcomes Adverse events Comments characteristics LichtenCountry/countries: No. Published studies of percutaneous heart valves (Questions 3-4) (continued) Study Study Patients Intervention Outcomes Adverse events Comments characteristics Marcheix, Country/countries: No. Published studies of percutaneous heart valves (Questions 3-4) (continued) Study Study Patients Intervention Outcomes Adverse events Comments characteristics Lopez de Age: 79 except complete transvenous Sa, et al. Published studies of percutaneous heart valves (Questions 3-4) (continued) Study Study Patients Intervention Outcomes Adverse events Comments characteristics et al. Published studies of percutaneous heart valves (Questions 3-4) (continued) Study Study Patients Intervention Outcomes Adverse events Comments characteristics Schofer, Country/countries: No. Published studies of percutaneous heart valves (Questions 3-4) (continued) Study Study Patients Intervention Outcomes Adverse events Comments characteristics aortic valve annulus Survival: diameter?
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Data from different study sites were pooled for staA total of 188 female and 146 male subjects were screened, tistical analysis. All the randomized subjects who had a and 141 female and 128 male subjects were randomized to baseline and at least one post-randomization evaluation receive the lasercomb or sham device. To account female and 25 male subjects were lost to follow-up, leaving for dropouts thereafter, all data are presented in last 122 female and 103 male subjects completing at least one observation carried forward for the analysis of covariance follow-up. The lasercomb-treated subjects in demographic characteristics or hair loss features showed a much higher increase in terminal hair density between the lasercomb and sham group in any of the four compared with sham-treated subjects, with a mean of 20. Similar improvement in terminal hair denfollow-up was conducted after 26 weeks of treatment, an sity was observed with the 12-beam lasercomb treatment in accepted standard for clinical trials on hair growth. Dates of recruitments are 10/28/09 02/18/10 02/01/10 09/28/10 08/25/09 01/08/10 07/29/09 12/11/09 indicated Subjects screened Subjects screened Subjects screened Subjects screened N=117 N=71 N=57 N=89 Did not meet criteria Did not meet criteria Did not meet criteria Did not meet criteria n=39 n=8 n=8 n=10 Randomized: n=78 Randomized: n=63 Randomized: n=49 Randomized: n=79 9-beam n=25, 9-beam n=53, 12-beam n=42, 7-beam n=33, 12-beam n=28, Sham n=25 Sham n=21 Sham n=16 Sham n=26 16-week follow-up: 16-week follow-up: 16-week follow-up: 16-week follow-up: n=65 n=65 n=57 n=38 9-beam n=21, 9-beam n=43, 12-beam n=39, 7-beam n=24, 12-beam n=22, Sham n=22 Sham n=18 Sham n=14 Sham n=22 Lost to follow-up/ Lost to follow-up/ Lost to follow-up/ Lost to follow-up/ consent consent withdrawal: consent withdrawal: consent withdrawal: withdrawal: n=13 n=6 n=11 n=14 26-week follow-up: 26-week follow-up: 26-week follow-up: 26-week follow-up: 9-beam n=21, 9-beam n=42, 12-beam n=39, 7-beam n=24, 12-beam n=19, Sham n=21 Sham n=18 Sham n=14 Sham n=21 Lost to follow-up: Lost to follow-up: Lost to follow-up: Lost to follow-up: n=2 n=0 n=0 n=4 Efficacy n=65 Efficacy n=57 Efficacy n=38 Efficacy n=65 120 J. Table 1 Demographic characteristics of female subjects at baseline for the 9and 12-beam lasercomb trials Trial #1 (n = 65) Trial #2 (n = 57) 9-beam lasercomb Sham p value 12-beam lasercomb Sham p value Number of subjects 43 22 39 18 Age (years) 0. Additionally, none of the 43 lasercomb-treated from baseline between lasercomb and sham treatment was subjects showed decreased hair density as opposed to 11 of highly signi? In Trial #2, 37 of 39 (95 %) of the 12-beam sham treatment in both male trials (Trial #3, 7-beam lasercomb-treated female subjects had hair density 2 lasercomb vs. In Trial #1, 41 of 43 (95 %) of the the 24 (8 %) lasercomb-treated male subjects showed Lasercomb Treatment of Male and Female Pattern Hair Loss 121 Table 2 Demographic characteristics of male subjects at baseline for the 7-, 9-, or 12-beam lasercomb trials Trial #3 (n = 38) Trial #4 (n = 65) 7-beam Sham p value 9-beam 12-beam Sham p value lasercomb lasercomb lasercomb Number of subjects 24 14 21 22 22 Age (years) 0. A higher percentage of lasercomb-treated subjects reported Whereas 9 of 22 (41 %) sham-treated subjects showed overall improvement of hair loss condition and thickness decreased hair density, only 3 of 21 (14 %) 9-beam laserand fullness of hair in self-assessment, compared with comb-treated subjects and 4 of 22 (18 %) 12-beam lasersham-treated subjects (Table 3). In the pooled male subject trials, using three different lasercomb models in both male and assessment of the thickness and fullness of hair reached female subjects showed improvement in terminal hair statistical signi? Global photographs of a female subject, at baseline (a) and after 26 weeks (b) of the 12-beam lasercomb treatment. Macrophotographs of a male subject, at baseline (c) and after 26 weeks (d) of the 9-beam lasercomb treatment. Increased hair count through conversion of vellus or intermediate follicles to active follicles producing terminal hair (ovals) or resting telogen to active anagen follicles (rectangles)is highlighted 3. A higher Study Duration, and Gender percentage of lasercomb-treated subjects reported overall improvement of hair loss condition and thickness and Meta-analyses were conducted to provide an overall fullness of hair in self-assessment, though the results did assessment of the individual study results. The homogeneity assessment results were receiving the lasercomb in any of the four trials. These results indicated that lasercomb-related adverse events included dry skin compared with sham treatment, lasercomb treatment (5.