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Falling back, I was relieved to feel him drowning irretrievably in my blood, which was filling every depth, flooding every shore. I had been standing at the helm in the dark night, a feeble lantern burning over my head, and now this man had come and tried to push me aside. And as I would not yield, he put his foot on my chest and slowly crushed me while I still clung to the hub of the helm, wrenching it around in falling. I soon collected myself, however, ran to the hatchway which gave on to the mess quarters, and cried out: "Men! As soon as the top began to spin the philosopher went in pursuit and tried to catch it. He was not perturbed when the children noisily protested and tried to keep him away from their toy; so long as he could catch the top while it was still spinning, he was happy, but only for a moment; then he threw it to the ground and walked away. For he believed that the understanding of any detail, that of a spinning top, for instance, was sufficient for the understanding of all things. For this reason he did not busy himself with great problems, it seemed to him uneconomical. Once the smallest detail was understood, then everything was understood, which was why he busied himself only with the spinning top. And whenever preparations were being made for the spinning of the top, he hoped that this time it would succeed: as soon as the top began to spin and he was running breathlessly after it, the hope would turn to certainty, but when he held the silly piece of wood in his hand, he felt nauseated. The screaming of the children, which hitherto he had not heard and which now suddenly pierced his ears, chased him away, and he tottered like a top under a clumsy whip. At the beginning it was so big that I was afraid, I kept running and running, and I was glad when at last I saw walls far away to the right and left, but these long walls have narrowed so quickly that I am in the last chamber already, and there in the corner stands the trap that I must run into. A torn piece of cloth, once wound around a stick in a game, flutters in the breeze. What use can I be to them, what do I mean to them, even though I am the son of my father, the old farmer And since I am listening from a distance, I hear nothing but a faint striking of the clock passing over from childhood days, but perhaps I only think I hear it. Whatever else is going on in the kitchen is the secret of those sitting there, a secret they are keeping from me. All his needs, very modest needs at that, were supplied by relays of attendants who watched from below and sent up and hauled down again in specially constructed containers whatever he required. This way of living caused no particular inconvenience to the theatrical people, except that, when other turns were on the stage, his being still up aloft, which could not be dissembled, proved somewhat distracting, as also the fact that, although at such times he mostly kept very still, he drew a stray glance here and there from the public.

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Yet perhaps I may venture to assert on the basis of the many writings on this subject which I have read, as well as from my own observation the building of the wall in particular, with its abundance of human material, provided a man of sensibility with the opportunity of traversing the souls of almost all the provinces on the basis of all this, then, perhaps I may venture to assert that the prevailing attitude to the Emperor Page 278 shows persistently and universally something fundamentally in common with that of our village. Now I have no wish whatever to represent this attitude as a virtue; on the contrary. True, the essential responsibility for it lies with the government, which in the most ancient empire in the world has not yet succeeded in developing, or has neglected to develop, the institution of the empire to such precision that its workings extend directly and unceasingly to the farthest frontiers of the land. On the other hand, however, there is also involved a certain feebleness of faith and imaginative power on the part of the people, that prevents them from raising the empire out of its stagnation in Peking and clasping it in all its palpable living reality to their own breasts, which yet desire nothing better than but once to feel that touch and then to die. All the more remarkable is it that this very weakness should seem to be one of the greatest unifying influences among our people; indeed, if one may dare to use the expression, the very ground on which we live. To set about establishing a fundamental defect here would mean undermining not only our consciences, but, what is far worse, our feet. And for that reason I shall not proceed any further at this stage with my inquiry into these questions. In keeping with the importance of this much-discussed hour, I can recall the smallest details. My father was holding me by the hand, something he was fond of doing to the end of his days, and running his other hand up and down his long, very thin pipe, as though it were a flute. With his sparse, rigid beard raised in the air, he was enjoying his pipe while gazing upwards across the river. At that moment a bark drew up before us, the boatman beckoned to my father to come down the embankment, while he himself climbed up toward him. I could not understand what they said, I only saw that my father did not seem to believe the news, that the boatman tried to insist upon its truth, that when my father still refused to believe it the boatman, with the passion of sailors, almost tore the garment from his chest to prove the truth, whereupon my father fell silent and the boatman jumped noisily into the bark and sailed away. Deep in thought my father turned toward me, knocked his pipe out and stuck it in his belt, stroked my cheek, and pulled my head toward him. There the rice pap was already steaming on the table, several guests had assembled, the wine, was just being poured into the goblets. Paying no attention to any of this and having advanced no farther than the threshold, my father started telling what he had heard. Of the exact words I have of course no recollection, but owing to the exceptional circumstances which cast a spell even over the child, the meaning Page 280 became so clear to me that I venture nevertheless to give some version of what my father said. My father said something like this: An unknown boatman I know all those who usually pass by here, but this one was a stranger has just told me that a great wall is going to be built to protect the Emperor. For it seems that infidel tribes, among them demons, often assemble before the imperial palace and shoot their black arrows at the Emperor.

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Benylin Night (paracetamol 500 mg + diphenhydramine hydrochloride 25 mg) 1 x/ day before sleeping Control: paracetamol 500 mg Duration: 5 days Outcomes 1. Intake of any medications/supplements within the previous 24 hours for cold symptoms or pain relief or that could produce drowsiness or promote alertness, intake of any antihistamines within the previous 72 hours, of any sedatives within the previous week, of any antidepressants within the previous 3 weeks Duration of symptoms before inclusion: 1 to 5 days Interventions Intervention: 1 evening dose of 30 ml containing 15 mg dextromethorphan hydrobro mide, 7. No information on sequence gen eration Allocation concealment (selection bias) Unclear risk No information provided Blinding (performance bias and detection Unclear risk No reporting of blinding of participants, bias) researchers or assessors. Objective measures including mucus and tissues weight, nasal patency measurements 3. Ratingon5-point scale of efcacy on: nasal obstruction, rhinorrhoea, sneezingcough* 2. Thackray 1978 (Continued) Duration of symptoms before inclusion: not mentioned Interventions Active syrup containing: paracetamol 600 mg, dextromethorphan hydrobromide 15 mg, ephedrine sulphate 8 mg, doxylamine succinate 7. Rating on 6-point scale of efcacy of medication on: nasal congestion, nasal discharge, sneezing, cough and generally feeling unwell during the night* 2. Comparison of number of positive rating after 1 dose of active syrup or placebo syrup 3.

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If severe haemolysis occurs, or if the patient has had previous haemolytic reactions, options for treatment or prophylaxis include high-dose corticosteroids and intravenous immunoglobulin. Patients usually present several days after the last transfusion and it may, initially, 97 Handbook of Transfusion Medicine be diagnosed as an acute sickle cell crisis. Treatment with high-dose intravenous immunoglobulin has been effective in some reported cases but the benefits of corticosteroids are uncertain. The patients have much in common with patients in critical care in which there is evidence to support a restrictive red cell transfusion policy (see Chapter 7). However, very low haematocrits may increase the risk of bleeding in patients with severe thrombocytopenia. Over the last decade, most units have used a platelet transfusion threshold of 10109/L, largely based on an Italian trial comparing thresholds of 10 or 20109/L. A randomised controlled trial in north America recently showed no significant difference in bleeding rates when patients on prophylaxis were randomised to low, medium or high platelet doses. Most trials of platelet therapy looking at dose or transfusion threshold have shown no difference in bleeding rates between the trial arms, and the routine use of prophylactic platelet transfusion has been questioned. Both trials showed an overall increase in Grade 2 to 4 bleeding in the no-prophylaxis group. Although prophylactic platelets are beneficial in most patients receiving intensive chemotherapy they do not prevent all bleeding. Serious bleeds occur above the 10109/L threshold and current research is investigating clinical and laboratory risk factors. Based on current evidence: Prophylactic platelet transfusions should be given to patients receiving intensive chemotherapy, with a transfusion trigger of 10109/L. The platelet increment can be measured as early as 10 minutes after completion of the transfusion. Control of bleeding is the most clinically relevant marker but, in practice, it is usual to measure the increase in platelet count after transfusion. Formulas to derive platelet recovery or corrected count increment are of limited value outside research as they require knowledge of the platelet content of each unit transfused. In the clinical setting, simpler indicators, such as failure of the immediately post-transfusion (10 to 60 minutes) platelet increment to exceed the transfusion trigger or a rise of less than 10109/L 20 to 24 hours after transfusion, are used. The diagnosis of refractoriness should only be made after an unsatisfactory response to two or more transfusions. Platelet refractoriness can be due to immunological or, more commonly, non-immunological causes associated with increased platelet consumption or losses (Table 8. Immediate (10 to 60 minutes) and 24-hour post-transfusion platelet increments should be measured. A clear post-transplant transfusion policy should be developed for all transplant patients and circulated to the clinical and laboratory teams involved in their care. In RhD-incompatible transplants, the main risk is delayed haemolysis where the donor is RhD negative and the recipient RhD positive.

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