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It interferes with protein synthesis in eukaryotes by inhibiting peptidyltransferase activity of the 60S ribosomal subunit. Its main target appears to be the T H3C lymphocyte: it contains D-alanine and several nonprotein amino O acids, and blocks a calcium-dependent signal from the T-cell receptor that normally leads to T-cell activation. They contain fi30 residues, of which 6 are conserved cysteines, and cyclomaltoheptaose see cyclodextrin. Examples (from Rubiaceae family) include: circulins A and cyclomaltooctaose see cyclodextrin. The particles move dioxygen at C-9 and a second dioxygen at C-15 of a molecule of in spiral paths under the influence of a uniform vertical magnetic arachidonic acid, accompanied by formation of a bond between Cfield and are accelerated by a constant frequency electric field. Cyd symbol for a residue of the ribonucleoside cytidine (alternative to cyclophilin a protein of the immunophilin class that binds the imC). Cyclophilin possesses peptidylprolyl CydP symbol for cytidine phosphate (see cytidine phosphate). Under physiological conditions it may have a Cyd2fiP symbol for cytidine 2fi-phosphate (see cytidine phosphate). Cy3 dye a proprietary name for an orange fluorescent cyanine dye cyclophosphamide N,N-bis(2-chloroethyl)tetrahydro-2H-1,3,2having k excitation 550 nm and k emission 570 nm. Cy5 dye a proprietary name for a sulfoindocyanine dye having kmax these are transported to tissues, which convert them to the cytoexcitation 649 nm and kmax emission 670 nm, and uses similar to toxic agent, phosphoramine mustard, and acrolein. It is usually benign, pyridoxine-responsive, and the secretion of gonadotropins and spermatogenesis in humans. Cyr61 a growth factor binding protein expressed from G0/G1 to midcystatin any of a group of proteins, present in tissues and body fluG1 of the cell cycle. Family 3 proteins (also called kininogens) contain three cysit represents L-half-cystine. Examples: cystatin A (also prising a central cavity lined with epithelium and containing fluid called stefin A); type 2 cystatin C (also called neuroendocrine basic or semisolid material. They are commonly encountered during sequencing of peptides and proteins as the end product O H N H of oxidative cleavage of the disulfide bonds of cystine residues and 2 S concomitant oxidation of cysteine residues. The enzyme carries out the final reaction in cysteine the trivial name for b-mercaptoalanine; a-amino-b-thiol2 the pathway for the synthesis of cysteine from methionine. In neutral or alkaline sohydro-lyase (adding homocysteine); other names: serine sulfhylution it is readily oxidized by air to cystine.

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Sulfhydryl In selecting a surgeon or center for primary cancer compounds interfere with free radical generation and treatment, consideration must be given to the volume may act as radiation protectors. Studies in a Most radiation-induced cell damage is due to the forvariety of cancers have shown that increased annual mation of hydroxyl radicals: procedure volume appears to correlate with outcome. Surgical bypass of gastroina particular cell more sensitive or more resistant to the testinal, urinary tract, or biliary tree obstruction can allebiologic effects of radiation are not completely defined. Surgical procedures Although radiation can interfere with many cellular may provide relief of otherwise intractable pain or processes, many experts believe that a cell must undergo reverse neurologic dysfunction (cord decompression). Intrathecal or intrahepatic therapy relies on surinclude the D0 of the tumor (the dose required to gical placement of appropriate infusion portals. Plastic and reconstructance and aimed at the tumor within the patient; (2) tive surgery can correct the effects of disfiguring pribrachytherapy,with encapsulated sources of radiation mary treatment. The fraction of cells surviving is plotted on a logaportional to dose (D), while the other is proportional to the rithmic scale against dose on a linear scale. The dose at which the linear and cles or low-energy neutrons (said to be densely ionizing), the quadratic components are equal is the ratio /. For x-rays the curve is described by the initial slope (D1), the final slope or gamma rays (said to be sparsely ionizing), the dose(D0), and a parameter that represents the width of the shoulresponse curve has an initial linear slope, followed by a shoulder, either n or Dq. Teletherapy is the most combeams have a very low tissue penetrance and are used to monly used form of radiation therapy. Neutron Radiation from any source decreases in intensity as a beams may be somewhat more effective than x-rays in function of the square of the distance from the source treating salivary gland tumors. Thus, if the radiation source is 5 cm specialized uses, particulate forms of radiation such as above the skin surface and the tumor is 5 cm below the neutrons, protons, and negative mesons, which should skin surface, the intensity of radiation in the tumor will do more tissue damage because of their higher linear be 52/102, or 25% of the intensity at the skin. By conenergy transfer and be less dependent on oxygen, have trast, if the radiation source is moved to 100 cm from not yet found wide applicability to cancer treatment. Hypoxic cells are relatively resisTeletherapy maintains intensity over a larger volume of tant. Nondividing cells are more resistant than dividing target tissue by increasing the source-to-surface distance. In addition to these biologic parameters, physical In brachytherapy, the source-to-surface distance is small; parameters of the radiation are also crucial. They are both when they strike the body, much like light diffuses when electromagnetic, nonparticulate waves that cause the it strikes particles in the air.

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See also blaslected (in registers), the word registry has also toma; carcinoembryonic antigen test; desmoid come to mean the collection itself. A tumor registry tumor; ear tumor; epidermoid carcinoma; epitheis organized so that the data can be analyzed. For lial carcinoma; esophageal cancer; fibroid; example, analysis of data in a tumor registry mainsyringoma; tumor marker. The tunica albuginea helps to trap a tumor, because no tumor marker is entirely spethe blood in the corpora cavernosa, thereby sustaincific to a particular type of cancer, and because not ing erection of the penis. An example of a tunnel is when a particular tumor has been found with a the carpal tunnel. Tympanometry works by varying ized by polyps in the colon (large intestine) in addithe pressure within the ear canal and measuring the tion to tumors in the brain. The intelligence of air (pneumothorax) or the abdomen is distended those with Turner syndrome is usually within the with gas. Girls with Turner syndrome at the time of puberty do not experience the development type I error See alpha error. The ovaries typically contain no follicles and look like streaks of fibrous tissue. A typhoid fever An acute illness characterized by second sex chromosome may be present, but it is fever caused by infection with the bacterium not structurally and functionally normal. Diarrhea is uncommon, overwhelming majority of pregnancies with Turner and vomiting is not usually severe. Large epidemics are most often related to fecal contaminatwin One of two children produced in the same tion of water supplies or foods sold on the streets. Twins who people traveling to high-risk areas, such as the develop from two ova that are fertilized at the same Indian subcontinent and developing countries in time are called dizygotic or fraternal twins. They are Asia, Africa, and Central and South America where nonidentical and have different genomes. Typhoid vaccination is not tympanic membrane the eardrum, a thin mem100 percent effective and is not a substitute for brane that serves as a partition between the external careful selection of food and drink.

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Oxidant drugs, diabetic ketoacidosis, and the newborn period are other precipitating events. A new steady state is reached and the anemia improves even if the oxidant stress continues. When subjected to oxidant stress, severe intravascular hemolysis with profound anemia, hemoglobinuria, and jaundice may occur. As in the mild types, infection is the most common precipitating event and the hematocrit is normal between episodes. It is believed that a second hereditary defect is required in which an ingredient of the beans is aberrantly metabolized to an active oxidant. A number of other drugs are probably not safe for patients with the congenital chronic hemolytic anemia variants. On the other hand, many drugs previously thought to be contraindicated, such as aspirin and acetaminophen, have been exonerated. Oxidized globin chains precipitate and form disulfide bridges to the red cell membrane, rendering the cell undeformable. Molecular Physiology Normal adult hemoglobin contains four globin chains, two alpha and two beta. One hemoglobin molecule combines reversibly with four molecules of oxygen to form oxyhemoglobin. The sigmoid shape of the oxygen equilibrium curve is a consequence of "heme-heme interaction," or "subunit cooperativity," with oxygen binding to the first heme increasing the strength of its binding by the second, the second increasing the strength of binding by the third, and so on. This characteristic of hemoglobin depends upon its tetrameric structure and on the presence of dissimilar chains in the tetramer (two alpha and two beta chains in the case of normal adult human hemoglobin). Thus, monomers such as myoglobin yield an oxygen equilibrium curve that is a rectangular hyperbola; as does a tetramer containing only beta chains (fi 4 =Hemoglobin H). An elegant explanation has been devised by Perutz to account for this shape of the oxygen equilibrium curve. There are ionic bonds within and between the alpha and beta chains, which stabilize the molecule. Rupture of salt bonds also causes subtle movement within the adjacent subunit such that the affinity of its iron for oxygen increases. The hemoglobin molecule, like the lung, thus "breathes" as oxygen comes and goes (Fig. The normal bloodoxygen equilibrium curve (middle curve) and leftand right-shifted curves.

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