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Another hospital improved survival of inpatients with heart failure (from 87% to 92%) and reduced 30-day readmission rates (from 24% to 15%) by increasing compliance with several guideline 46 recommendations for diagnosis, treatment and long-term management. Registries are the main source of real-world data on severity, causes, treatment, long-term management and outcomes for patients hospitalized with heart failure. They are less comprehensive than audits, because they do not attempt to include every patient. Although the majority of registries are set up only to collect data, it has been suggested that the feedback provided by the benchmarked reports produced by some registries can lead to improvements in guideline adherence. To date, most data collected in registries is from North America or Western Europe; however, the underlying causes of heart failure are different in other parts of the world. Heart failure registries therefore need to be set up in more regions to improve global understanding of how heart failure develops and how it can be prevented. Professional initiatives can offer advice and support for improving compliance with guidelines. Hospitals sign up to use a performance-improvement tool that records data and assists with decision-making, and good performers receive public recognition. A survey of hospitals taking part in the programme showed that improved discharge and transitional care processes reduced 30-day readmission rates for patients with heart failure, although other 142 strategies examined in the survey were not associated with improved patient outcomes. Many countries impose penalties on hospitals for all readmissions within 30 days of discharge. These penalties are designed to reduce preventable readmissions, but there is concern that they may unfairly punish hospitals with good survival rates, and that they may in fact reflect variations in standards of 144 community care after discharge rather than care in hospital. Care pathways Compliance can be encouraged through the use of care pathways, which are guideline-based systematic plans for the care of particular patients over a specific time period. These short checklists focus on improving diagnosis (via expert review), improving treatment (via evidence-based prescription) and improving long-term management (via referral to a heart failure nurse service); initial results show promise in improving 148 survival rates. Improving the performance of healthcare services by providing incentives and management systems that encourage compliance with guidelines is a powerful tool for policy-makers. It is not necessarily safe to assume, however, that patients with heart failure will enjoy longer life and a reduced chance of hospital readmission as a result of even nominally successful performance improvement programmes. Just as medications and devices have to be tested in clinical trials to show that they are effective and safe, it has been argued that management strategies should also be supported by robust scientific evidence before they are mandated by organizations that pay for 149 healthcare. Policy-makers should fund and encourage activities that build an evidence base for driving improved care and outcomes for patients with heart failure. There is a pressing need for research into evidence-based healthcare performance measures that reflect improved clinical outcomes for patients with heart failure. In parallel, more widespread data collection via audits or registries should be implemented where country-level initiatives are not already in place. Future directions in care: urgent unmet needs There are urgent unmet needs at all stages of heart failure care (Figure 9).

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There is no convincing evidence that airborne infections occur and faeces are not a source of infection, since the virus is inactivated by enzymes of the intestinal mucosa or derived from the bacterial flora. However, only blood, vaginal and menstrual 15, 23, 30, 31 fluids, and semen have been shown to be infectious. Transmission occurs by percutaneous and permucosal exposure to infective body fluids. Immune globulins, heat-treated plasma protein fraction, albumin and fibrinolysin are considered safe when manufactured appropriately. Closely related hepadnaviruses have been found in woodchucks 10 and ducks, but they are not infectious for humans. Experimental infections of woolly monkeys, tamarins, and other primate species have generally been unsatisfactory. Surgeons, dentists, oral surgeons, pathologists, operating room and emergency room staff, and 31 clinical laboratory workers who handle blood are at the highest risk. Efforts to vaccinate persons in the major risk groups have had limited success because of the difficulties in identifying vaccination candidates belonging to high risk groups. Moreover, regulations have to be 3, 37 developed to ensure the implementation of vaccination programs. However, case definitions vary, laboratory confirmation is not always used, reporting systems differ, and distinctions are not always made between the types of viral hepatitis. The serological quality of the test used is crucial for firm diagnosis of infection. Regardless of the availability of serological tests, all countries are advised to report all cases of jaundice and suspected viral hepatitis. Countries with laboratory facilities can differentiate further between hepatitis A, B, C, and other types of hepatitis. Hepatitis B is highly endemic in all of Africa, some parts of South America, Alaska, northern Canada and parts of Greenland, eastern Europe, the eastern Mediterranean area, south-east Asia, China, and the Pacific Islands, except Australia, New Zealand and Japan. Incidence/Epidemiology 15, 38 the hepatitis B virus is a ubiquitous virus with a global distribution. In low-risk areas of the world, the highest incidence of the disease is seen in teenagers and young adults. Nevertheless, the availability of an effective vaccine, optimized blood donor screening, and better 15 sterilization procedures for blood derivatives have lowered substantially the infection risk.

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Naturally or experimentally infected nonhuman primates are a proven source of human infection. Experimentally infected guinea pigs or mice do not pose the same problem since droplet nuclei are not produced by coughing in these species; however, litter from infected animals may becom e contaminated and serve as a source of infectious aerosols. Laboratory Hazards: Tubercle bacilli may be present in sputum, gastric lavage fluids, cerebrospinal fluid, urine, and in lesions 74, from a variety of tissues. Exposure to laboratory-generated aerosols is the most important hazard encountered. Tubercle 75, bacilli may survive in heat-fixed smears, and may be aerosolized in the preparation of frozen sections and during manipulation of liquid cultures. Recommended Precautions: Biosafety Level 2 practices and procedures, containment equipment, and facilities are required for non-aerosol-producing manipulations of clinical specimens such as preparation of acid-fast smears. Biosafety Level 3 practices, containment equipment, and facilities are required for laboratory activities in the propagation and manipulation of cultures of M. Animal studies utilizing guinea pigs or mice can be conducted at Animal Biosafety 79, Level 2. Agent: Neisseria gonorrhoeae Laboratory-associated gonococcal infections have been 80, reported in the United States. Laboratory Hazards: the agent may be present in conjunctival, urethral and cervical exudates, synovial fluid, urine, feces, and cerebrospinal fluid. Accidental parenteral inoculation and direct or indirect contact of mucous membranes with infectious clinical materials are the known primary laboratory hazards. Gloves should be worn when handling infected laboratory animals and when there is the likelihood of direct skin contact with infectious materials. Additional primary containment and personnel precautions, such as those described for Biosafety Level 3, may be indicated for aerosol or droplet production, and for activities involving production quantities or concentrations of infectious materials. Agent: Neisseria meningitidis Meningococcal meningitis is a demonstrated but rare hazard 81,82, 83, to laboratory workers. Laboratory Hazards: the agent may be present in pharyngeal exudates, cerebrospinal fluid, blood, and saliva. Parenteral inoculation, droplet exposure of mucous membranes, infectious aerosol and ingestion are the primary hazards to laboratory personnel. Recommended Precautions: Biosafety Level 2 practices, containm ent equipm ent, and facilities are recom mended for all activities utilizing known or potentially infectious body fluids, tissues, and cultures. Additional primary containment and personnel precautions, such as those described for Biosafety Level 3, may be indicated for activities with a high potential for droplet or aerosol production and for activities involving production quantities or concentrations of infectious materials. Agent: Salmonella all serotypes except typhi Salmonellosis is a documented hazard to laboratory person84,85,86, nel. Primary reservoir hosts include a broad spectrum of domestic and wild animals, including birds, mammals, and reptiles, all of which may serve as a source of infection to laboratory personnel.

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Generally, the following small, homogeneous, poorly-defined, grey-white mass features are present: without any sharp demarcation between the tumour and 1. The tumour of of disease in cases with carcinoma head of the pancreas (80%), the head extends into the ampulla of Vater, common bile and less often in cancer of the body and tail of the pancreas. Microscopically, most pancreatic carcinomas arise from the prognosis of pancreatic cancer is dismal: median the ductal epithelium which normally comprises less than survival is 6 months from the time of diagnosis. Approxi4% of total pancreatic cells, whereas carcinoma of the acini mately 10% patients survive 1 year and the 5-year survival is poor 1 to 2%. The kidneys are bean-shaped paired organs, each weighing about 150 gm in the adult male and about 135 gm in the adult female. The hilum of the kidney is situated at the midpoint on the medial aspect where the artery, vein, lymphatics and ureter are located. The kidney is surrounded by a thin fibrous capsule which is adherent at the hilum. Cut surface of the kidney shows 3 main structures: welldemarcated peripheral cortex, inner medulla and the innermost renal pelvis (Fig. Remaining 15% nephrons consisting of collecting tubules, collecting ducts, loops of Figure 22. This latter part of the cortex forms faint striations called medullary rays, a of each renal pyramid for passage of urine collected from misnomer since theses structures are located in the cortex collecting ducts and goes down into minor calyces. Columns of renal cortical tissue the renal pelvis is the funnel-shaped collection area of that extend into the space between adjacent pyramids are the urine for drainage into the ureter. The minor calyces (8called the renal column (septa) of Bertin; they contain the 18 in number in a normal kidney) collect urine from renal interlobar arteries. The base of a renal pyramid lies adjacent to the of approximately one million microstructures called outer cortex and forms the cortico-medullary junction, while nephrons. From point of view of diseases of the kidneys, 4 components of renal parenchyma require further elaboration: renal vasculature, glomeruli, tubules and interstitium. Each kidney is supplied with blood by a main renal artery which arises from the aorta at the level of the 2nd lumbar vertebra. It usually divides into anterior and posterior divisions at the hilum although occasionally these divisions may even arise directly from the aorta. The anterior and posterior divisions divide into segmental branches from which interlobar arteries arise which course between the lobes. Along their course, they give off the arcuate arteries which arch between the cortex and medulla.