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Because alcohol is a depressant, when it is combined with other depressants (tranquilizers and barbiturates), the effects can be deadly. Since most people do not think of alcohol as a drug, but rather as a beverage, many people are not aware of the dangers. These combinations magnify the effects of each other and result in unpredictable behavior, impaired skill levels, and unnecessary risks to health and safety. The risks become even greater when the user is not aware of the presence of the other drugs and is caught by surprise with more than he/she bargained for. Combining cocaine with alcohol or other depressants results in significant physical trauma as the two drugs are giving the body two opposite messages. Cocaine mixed with other stimulants greatly intensifies the effects of both drugs. The result is increased blood pressure and heart rate often resulting in heart attack, stroke, brain seizure and/or death. The resulting effects on job performance and skill levels will be more dramatic and longer lasting with the use of a combination of drugs. Attempting to perform basic skills may become very difficult and dangerous, compromising public and personal safety. Discussion View Graph 10-4 How can a responsible person avoid the risks associated with combining drugsfi Do not combine any drugs or alcohol unless specifically directed to do so by a physician or pharmacist. Be careful to read warning labels and ask your physician how the drugs may interact and how that will affect your skill level and job performance. The combination of alcohol with tranquilizers is often cited as a deadly combination, as is the combination of cocaine and other stimulants. However, any combination of drugs can be dangerous and should be avoided unless a physician or pharmacist directs their use. Combining Drugs 57 How much of the drugs or alcohol must be taken before the dangerous consequences are experiencedfi When she got the prescription filled she realized that the dosage (1 tablet every six hours) was less than the dosage (2 tablets every six hours) that she had taken in the past. Larry did not have time to eat lunch since he spent his whole break in the pharmacy. Read each label and underline the statements that a responsible public transit professional should be concerned about. Module 9: Over-the-Counter Drugs Exercise the labels from several over-the-counter medications are provided below. Do not combine any drugs or alcohol unless specifically directed by a. To describe th e dangers to public and personalsafety associated w ith th e use or m isuse ofprescription drugs.
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Relationship between prostate specific antigen and indexes of prostate volume in Japanese men. Prostate volume changes over time: results from the Baltimore Longitudinal Study of Aging. Age-related differences in internal prostatic architecture on transrectal ultrasonography: results of a community based survey in Japan. Natural history of benign prostatic enlargement: long-term longitudinal populationbased study of prostate volume doubling times. Long-term effects of finasteride in patients with benign prostatic hyperplasia: a double-blind, placebo-controlled, multicenter study. The effect of finasteride on the risk of acute urinary retention and the need for surgical treatment among men with benign prostatic hyperplasia. A population-based study of health care-seeking behavior for treatment of urinary symptoms. Treatment for benign prostatic hyperplasia among community dwelling men: the Olmsted County study of urinary symptoms and health status. The natural history of patients with benign prostatic hyperplasia as diagnosed by North American urologists. Natural history of benign prostatic hyperplasia: appropriate case definition and estimation of its prevalence in the community. Cumulative prevalence of prostatism matches the autopsy prevalence of benign prostatic hyperplasia. Benign prostatic hyperplasia in elderly Thai men in an urban community: the prevalence, natural history and health related behavior. Concordance rates for benign prostatic disease among twins suggest hereditary influence. Polymorphisms in genes involved in sex hormone metabolism may increase risk of benign prostatic hyperplasia. Prospective study of serum dihydrotestosterone and subsequent risk of benign prostatic hyperplasia in community dwelling men: the Rancho Bernardo Study. Serum steroid and sex hormone-binding globulin concentrations and the risk of incident benign prostatic hyperplasia: results from the prostate cancer prevention trial. Relationship between serum testosterone and measures of benign prostatic hyperplasia in aging men. A prospective study of plasma hormone levels, nonhormonal factors, and development of benign prostatic hyperplasia.
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Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators. The role of endogenous catechol quinones in the initiation of cancer and neurodegenerative diseases. Effects of estradiol, 4-hydroxyestradiol and estradiol 2,3and 3,4the results of the research described here suggest that prevention quinones on mutagenesis in vivo and in vitro. Mutagenic activity of 4-hydroxyestradiol, a successful approach to preventing tumor development. The role of endogenous catechol quinones in the initiation of estrogen quinones with glutathione, and (4) limiting the levels of estrocancer and neurodegenerative diseases. In addition, there are a variety of natural products that could be used to 1993:57(2-3):237-257. Functional role of estrogen metabolism in target cells: review and modulate the enzymes involved in estrogen metabolism, thereby limitperspectives. Molecular origin of cancer: catechol estrogenerate the mutations leading to cancer. S 120 M anaging Biotransform ation: the M etabolic, Genom ic, and D etoxification Balance Points 13th International Sym posium of Rogan the Institute for Functional M edicine 26. The role of endogenous catechol quinones in the adducts: implications for tumor-initiating activity. Mutagenic activity of 4-hydroxyestradiol, quinones on mutagenesis in vivo and in vitro. Induction at high incidence of ductal prostate adenocarci2-hydroxyestradiol induce mutations in human breast epithelial cells. A critical approach to the malignant transformation of adducts: implications for tumor-initiating activity. Minisymposium on endogenous carcinogens: the catechol estrogen path2004;15(5):211-214. The concept of stem cell in the mammary gland and chronic administration of estradiol to male Syrian hamsters. Spectral characterization of catechol estroinitiation of cancer and neurodegenerative diseases. Metabolism of stilbene estrogens and steroidal estrogens in relation to carestrogen metabolites and conjugates in mammary tumors and hyperplastic tissue from cinogenicity. Relative imbalances in estrogen metabolism and conjugation in breast tissue of women with carcinoma: potential biomarkers of susceptibility to cancer.
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Pregnant and postpartum Soldiers must be cleared by their health care provider prior to participating in physical fitness training. Wearing of individual body armor and/or any other additional equipment is not recommended and must be avoided after 14 weeks gestation. The Soldier is exempt from participating in swimming qualifications, drown proofing, field duty, and weapons training. Her workweek should not exceed 40 hours and the Soldier must not work more than 8 hours in any 1 day. A woman who is experiencing a normal pregnancy may continue to perform military duty until delivery. Only those women experiencing unusual and complicated problems (for example, pregnancy-induced hypertension) will be excused from all duty, in which case they may be hospitalized or placed sick in quarters. A pregnant Soldier will not be placed sick in quarters solely on the basis of her pregnancy unless there are complications present that would preclude any type of duty performance. Convalescent leave after a termination of pregnancy (for example, miscarriage) will be determined on an individual basis by the attending physician. Prior to commencing convalescent leave, postpartum Soldiers will be issued a postpartum profile. If a Soldier decides to return early from convalescent leave, the temporary profile remains in effect for the entire 45 days. Soldiers will receive clearance from the profiling officer to return to full duty. After receiving clearance from their health care provider to resume physical fitness training, postpartum Soldiers will take part in the postpartum physical fitness training element of the Army. The above guidance will only be modified if, upon evaluation of a physician, it has been determined the postpartum Soldier requires a more restrictive or longer profile because of complicated or unusual medical problems. Record medical conditions and/or physical defects in common usage, nontechnical language that a layman can understand. Code designations (defined in table 7-2) are limited to permanent profiles for administrative use only and are to be completed by the profiling officer. A Soldier may have a permanent profile for one condition and a temporary profile for another. If the profile is permanent, the profiling officer must assess if the Soldier meets retention standards of chapter 3 (Item 7). These functional activities are the minimum requirements to be considered medically qualified for military duties worldwide and under field conditions.